Prions and prion diseases
نویسندگان
چکیده
منابع مشابه
Prions and Prion Diseases: Current Perspectives
The viral encephalitides of Eastern, Western, and Venezuelan equine encephalitis viruses have been of public health concern for years. Over the last decade, several outbreaks caused by emerging zoonotic viral encephalitides, such as West Nile virus in North America and Nipah virus in Malaysia and Singapore in 1999, resulted in serious illnesses and deaths in persons, domesticated food animals, ...
متن کاملPrions' travels--feces and transmission of prion diseases.
The epidemiological profile of prion disease varies strikingly among different mammalian species. The overwhelming majority ( 90%) of prion diseases in humans are sporadic, with most of the remaining cases due to inherited mutations in the gene (PRNP) encoding the prion protein. Lateral transmission of disease between humans is extraordinarily rare. Most documented cases have been due to direct...
متن کاملPrions: Portable prion domains
Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
متن کاملPrions and prion-like proteins.
Prions are self-replicating protein aggregates and are the primary causative factor in a number of neurological diseases in mammals. The prion protein (PrP) undergoes a conformational transformation leading to aggregation into an infectious cellular pathogen. Prion-like protein spreading and transmission of aggregates between cells have also been demonstrated for other proteins associated with ...
متن کاملYeast Prions and Their Prion-Forming Domain
The focus of research on yeast prions is now moving to exploit this established and highly tractable model system to elucidate the molecular basis of prion conversion and to extrapolate these findings to mammalian prions. This of course raises the question of whether United Kingdom such extrapolation is valid. Yeast and Mammalian Prion Conversion: A Common Mechanism? Over a period of some 25 ye...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2007
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2006.05629.x